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KMID : 1202020080010010060
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Journal of Korean Thyroid Association
2008 Volume.1 No. 1 p.60 ~ p.65
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Relation between BRAF[V600E] Mutation and Ultrasonographic Findings in Papillary Thyroid Carcinoma
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Jo Young-Suk
Kim Jin-Man
Kim Yun-Jeung
Ro Heung-Kyu
Shong Min-Ho
Kim Song-Soo
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Abstract
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Background and Objectives: According to wide use of thyroid ultrasound (US), the incidence of thyroid cancer has been increased. Interestingly, a number of studies have reported specific sonographic findings might predict papillary thyroid carcinoma (PTC). However, there was no study which investigated the relation between oncogene and sonographic findings. In this study, we have investigated the effect of BRAFV600E mutation on sonographic findings.
Materials and Methods: We included 141 nodules from patients who underwent US-guided fine-needle aspiration biopsy (FNAB) and compared sonographic findings between PTC (n=55) and benign nodules (n=86). And then we have also compared sonographic findings according to presence or absence of BRAFV600E mutation.
Results: Expectedly, PTCs have frequently showed irregular shape, solid content, hypoechogenicity (29.1% vs 46.3%, p=0.04) and microcalcification (54.5% vs 26.7%, p=0.01) compared to benign nodules. In the case of PTC, 36 cases of 53 PTCs posed BRAFV600E mutation (BRAFV600E (+) PTC) and 17 cases did not (BRAFV600E (-) PTC). Lymph node enlargement, multifocality, solidity, poorly defined margin, irregular shape, hypoechogenicity and bilaterality were not significantly different between two groups. But, interestingly, microcalcification was more frequently detected in BRAFV600E (-) PTC (76.5%, p=0.03).
Conclusion: Compared with BRAFV600E (-) PTC, BRAFV600E mutation did not relate to malignant sonographic findings. This might represent that malignant sonographic findings were not BRAFV600E induced specific phenomenon.
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KEYWORD
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Thyroid neoplasm, Ultrasonography, Proto-Oncogene proteins B-raf
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